Latanoprost lactone diol

Names

[ Name ]:
Latanoprost lactone diol

[Synonym ]:
(3aR,4R,5R,6aS)-5-Hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]hexahydro-2H-cyclopenta[b]furan-2-one
LatanoprostLactoneDiol
2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]-, (3aR,4R,5R,6aS)-

Biological Activity

[Description]:

Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[References]

[1]. Pauly A, et al. In vitro and in vivo comparative toxicological study of a new preservative-free latanoprost formulation. Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8172-80.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
523.0±35.0 °C at 760 mmHg

[ Melting Point ]:
69-71ºC

[ Molecular Formula ]:
C₁₈H₂₄O₄

[ Molecular Weight ]:
304.381

[ Flash Point ]:
190.3±19.4 °C

[ Exact Mass ]:
304.167450

[ PSA ]:
66.76000

[ LogP ]:
0.60

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.568

Latanoprost lactone diol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds