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THP-PEG5-OH

Names

[ CAS No. ]:
146395-14-4

[ Name ]:
THP-PEG5-OH

[Synonym ]:
3,6,9,12-Tetraoxatetradecan-1-ol, 14-[(tetrahydro-2H-pyran-2-yl)oxy]-
14-(Tetrahydro-2H-pyran-2-yloxy)-3,6,9,12-tetraoxatetradecan-1-ol
MFCD26793753

Biological Activity

[Description]:

THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
432.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H30O7

[ Molecular Weight ]:
322.395

[ Flash Point ]:
215.4±28.7 °C

[ Exact Mass ]:
322.199158

[ LogP ]:
-1.82

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.469

Related Compounds