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Olanexidine hydrochloride

Names

[ CAS No. ]:
146509-94-6

[ Name ]:
Olanexidine hydrochloride

[Synonym ]:
Olanexidine hydrochloride
OPB2045

Biological Activity

[Description]:

Olanexidine hydrochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine hydrochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Olanexidine 显示出以下杀菌机制：(i) 与细菌表面分子相互作用，如脂多糖和脂磷壁酸；(ii) 破坏脂质体的细胞膜，这是人工细菌膜模型；(iii) 增强大肠杆菌的膜通透性；(iv) 破坏金黄色葡萄球菌的膜完整性，以及 (v) 在相对高浓度 (≥160 μg/ml) 下使蛋白质变性[1]。

[References]

[1]. Hagi A, et al. Bactericidal Effects and Mechanism of Action of Olanexidine Gluconate, a New Antiseptic. Antimicrob Agents Chemother. 2015 Aug;59(8):4551-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H28Cl3N5

[ Molecular Weight ]:
408.79700

[ Exact Mass ]:
407.14100

[ PSA ]:
88.99000

[ LogP ]:
6.66640

Related Compounds