Olanexidine

Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3].

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

Olanexidine (50 μM, 48 h) exhibits broad-spectrum bactericidal activity against Gram-positive cocci and Gram-negative bacteria[1]. Olanexidine (50 μg/mL, 24 h) inhibits chronic inflammatory reactions in oral mucosal cells[2]. Olanexidine (Olanexidine gluconate, 0-15000 μg/mL) inhibits the binding ability of virus-like particles to the binding receptor of human norovirus and increases the aggregation of virus-like particles[3]. Cell Viability Assay[1] Cell Line: Gram-positive cocci, Enterococcus spp., Gram-positive bacilli, Gram-negative strains Concentration: 0-1 mg/mL approximately Incubation Time: 30 s Result: Inhibited bacterial activity with MIC values ranging from 6.8 to 1740 μg/mL approximately.

Olanexidine (1 -2% in saline, applied to the skin) is active against transient or resident bacterial flora on the skin of male cynomolgus monkeys[4]. Animal Model: Male cynomolgus monkeys[4] Dosage: 1 %, 1.5%, 2% in saline Administration: Applied to the skin Result: Showed the fast-acting and long-lasting bactericidal effects at 1.5% concentration.