Mal-PEG3-alcohol

Names

[ Name ]:
Mal-PEG3-alcohol

[Synonym ]:
8-(N-maleimidyl)-3,6-dioxaoctan-1-ol
1H-Pyrrole-2,5-dione, 1-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-
1-{2-[2-(2-Hydroxyethoxy)ethoxy]ethyl}-1H-pyrrole-2,5-dione

Biological Activity

[Description]:

Mal-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
393.8±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅NO₅

[ Molecular Weight ]:
229.230

[ Flash Point ]:
192.0±23.7 °C

[ Exact Mass ]:
229.095016

[ LogP ]:
-1.25

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.521

Mal-PEG3-alcohol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds