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Pocapavir

Names

[ CAS No. ]:
146949-21-5

[ Name ]:
Pocapavir

[Synonym ]:
9602
Benzene, 1-((2-chloro-4-methoxyphenoxy)methyl)-4-((2,6-dichlorophenoxy)methyl)-
4ILA3VOV97
Benzene, 1-[(2-chloro-4-methoxyphenoxy)methyl]-4-[(2,6-dichlorophenoxy)methyl]-
Pocapavir
1,3-Dichloro-2-({4-[(2-chloro-4-methoxyphenoxy)methyl]benzyl}oxy)benzene

Biological Activity

[Description]:

Pocapavir is an investigational enterovirus (EV) capsid inhibitor.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Enterovirus
Research Areas >> Infection

[In Vitro]

Pocapavir acts as a capsid inhibitor, preventing virion uncoating upon entry into the cell. Treatment with Pocapavir is safe and significantly accelerates virus clearance[1]. Pocapavir, an investigational oral antiviral, has been used in a case of neonatal enterovirus sepsis. Pocapavir, also known as SCH 48973 and V-073, is a potent, selective anti-enteroviral agent only available as an emergency investigational drug. Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication[2].

[References]

[1]. Collett MS, et al. Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo-Controlled Human Oral Poliovirus Vaccine Challenge Model. J Infect Dis. 2017 Feb 1;215(3):335-343.

[2]. Wittekind SG, et al. Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment WithPocapavir. J Investig Med High Impact Case Rep. 2017 Sep 14;5(3):2324709617729393.


[Related Small Molecules]

Pleconaril | Pirodavir

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
541.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H17Cl3O3

[ Molecular Weight ]:
423.717

[ Flash Point ]:
176.5±28.8 °C

[ Exact Mass ]:
422.024323

[ LogP ]:
7.20

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.606

[ Storage condition ]:
2-8℃

Related Compounds