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DPM-1001

Names

[ CAS No. ]:
1471172-27-6

[ Name ]:
DPM-1001

Biological Activity

[Description]:

DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Metabolic Disease

[Target]

IC50: 100 nM (PTP1B)[1]


[References]

[1]. Krishnan N, et al. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H57N3O3

[ Molecular Weight ]:
567.85

Related Compounds