7ACC2

Names

[ Name ]:
7ACC2

[Synonym ]:
2H-1-Benzopyran-3-carboxylic acid, 7-[methyl(phenylmethyl)amino]-2-oxo-
7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
7ACC2

Biological Activity

[Description]:

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Monocarboxylate Transporter

Research Areas >> Cancer

[References]

[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.

[Related Small Molecules]

AZD3965 | UK-5099 | AR-C155858 | 7-Diethylaminocoumarin-3-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
548.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₅NO₄

[ Molecular Weight ]:
309.316

[ Flash Point ]:
285.8±30.1 °C

[ Exact Mass ]:
309.100098

[ LogP ]:
4.17

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.672

[ Storage condition ]:
2-8℃