PXS-4728A

Names

[ Name ]:
PXS-4728A

[Synonym ]:
PXS-4728A
(E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride
Benzamide, 4-(((2E)-2-(aminomethyl)-3-fluoro-2-propen-1-yl)oxy)-N-(1,1-dimethylethyl)-, hydrochloride (1:1)

Biological Activity

[Description]:

PXS-4728A is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO). PXS-4728A ameliorates chronic obstructive pulmonary disease in mice[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Inflammation/Immunology

[Target]

SSAO[1]

[References]

[1]. A G Jarnicki, et al. The Inhibitor of Semicarbazide-Sensitive Amine Oxidase, PXS-4728A, Ameliorates Key Features of Chronic Obstructive Pulmonary Disease in a Mouse Model. Br J Pharmacol. 2016 Nov;173(22):3161-3175.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₂ClFN₂O₂

[ Molecular Weight ]:
316.79900

[ Exact Mass ]:
316.13500

[ PSA ]:
64.35000

[ LogP ]:
4.29900

[ Storage condition ]:
-20°C

PXS-4728A

Names

Biological Activity

Chemical & Physical Properties

Related Compounds