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jmv 390-1

Names

[ CAS No. ]:
148473-36-3

[ Name ]:
jmv 390-1

[Synonym ]:
(2S)-2-[[(2S,3S)-2-[[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Jmv 390-1

Biological Activity

[Description]:

JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Doulut S, et al. Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J Med Chem. 1993 May 14;36(10):1369-79.

Chemical & Physical Properties

[ Density]:
1.177g/cm3

[ Molecular Formula ]:
C23H35N3O6

[ Molecular Weight ]:
449.54

[ Exact Mass ]:
449.25300

[ PSA ]:
155.30000

[ LogP ]:
4.40810

[ Index of Refraction ]:
1.536

Related Compounds