Ftivazide

Names

[ CAS No. ]:
149-17-7

[ Name ]:
Ftivazide

[Synonym ]:
4-Hydroxy-5-methoxy-benzaldehyd-isonicotinoylhydrazon
Isonicotinic acid vanillylidenehydrazide
Phthivazid
Phtivazide
Isonicotinsaeure-vanillylidenhydrazid
Ftivazide
Vancide
Vanizide
3-Methoxy-4-hydroxy-benzaldehyd-isonicotinoylhydrazon
Phthivazidum
Vanillaberon

Biological Activity

[Description]:

Ftivazide has anti-tuberculosis activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Dmitriy Khrustalev, et al. Synthesis of anti-tuberculosis drugs in a microwave flow reactor. Materials Today: Proceedings, 2023, 81: 1186-1191.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
441.6ºC at 760 mmHg

[ Melting Point ]:
219-220°C (lit.)

[ Molecular Formula ]:
C₁₄H₁₃N₃O₃

[ Molecular Weight ]:
271.27

[ Flash Point ]:
220.9ºC

[ Exact Mass ]:
271.09600

[ PSA ]:
83.81000

[ LogP ]:
1.95060

[ Vapour Pressure ]:
5.36E-08mmHg at 25°C

[ Index of Refraction ]:
1.619

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS2298000

CHEMICAL NAME :: Isonicotinic acid, vanillylidenehydrazide

CAS REGISTRY NUMBER :: 149-17-7

BEILSTEIN REFERENCE NO. :: 0234808

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H13-N3-O3

MOLECULAR WEIGHT :: 271.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24960 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 18(6),50,1972

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%