CGP 55845 hydrochloride

[Description]:

CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM. CGP55845 hydrochloride can be used for neurological research[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

In the mouse visual cortex, CGP 55845 hydrochloride (1 μM) increases the frequency of spontaneous Ca2+ transients and spontaneous and miniature IPSCs (mIPSCs) but does not affect mIPSC amplitudes or kinetics. CGP55845 hydrochloride significantly increases evoked IPSC (eIPSC) amplitudes and decreases the paired-pulse ratio (PPR)[3].

[In Vivo]

CGP55845 hydrochloride (i.p.; once; 0.5 mg/kg) treatment increases the number of PSD95 positive puncta as well as density and maturation of dendritic spines in the perirhinal cortex (PRC), and restores novel object recognition (NOR) memory in Cdkl5 KO mice[1]. Animal Model: Cdkl5 +/Y and Cdkl5 -/Y male mice (2-month-old)[1] Dosage: 0.5 mg/kg Administration: i.p.; once Result: Altered NOR recognition memory in Cdkl5 -/Y mice

[References]

[1]. Laura Gennaccaro, et al. A GABA B receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder. Neurobiol Dis. 2021 Jun;153:105304.

[2]. Claire-Marie Vacher, et al. GABA(B) receptors as potential therapeutic targets. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):248-59.

[3]. Knut Kirmse, et al. Ambient GABA constrains the strength of GABAergic synapses at Cajal-Retzius cells in the developing visual cortex. J Neurosci. 2006 Apr 19;26(16):4216-27.

[ Density]:
1.332g/cm3

[ Boiling Point ]:
647.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₂Cl₂NO₃P

[ Molecular Weight ]:
402.25200

[ Flash Point ]:
345.6ºC

[ Exact Mass ]:
401.07100

[ PSA ]:
79.37000

[ LogP ]:
4.86640

[ Vapour Pressure ]:
1.14E-17mmHg at 25°C

[ Index of Refraction ]:
1.591

Click to get detail MSDS

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
SZ4680000

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