1,2,3,4,6-O-Pentagalloylglucose

Names

[ Name ]:
1,2,3,4,6-O-Pentagalloylglucose

[Synonym ]:
β-D-Glucopyranose, pentakis(3,4,5-trihydroxybenzoate)
1,2,3,4,6-Pentakis-O-galloyl-β-D-glucose
1,2,3,4,6-O-pentagalloylglucose
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose
[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
1,2,3,4,6-Pentagalloyl glucose
Pentagalloylglucose
1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose
1,2,3,4,6-Pentakis-O-(3,4,5-trihydroxybenzoyl)-β-D-glucopyranose
1,2,3,4,6-Penta-O-galloyl-b-D-glucose
β-1,2,3,4,6-Pentagalloylglucose

Biological Activity

[Description]:

1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose is a gallotannin isolated from various plants. It suppressed interleukin (IL)-4 induced signal pathway in B cell, and inhibited IgE production partially caused by increasing a population of Treg cells in conjunction with Treg-inducing factors.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Saccharides and Glycosides

[References]

[1]. Viswanatha GL, et al. Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica. Eur J Pharmacol. 2013 Nov 15;720(1-3):286-93.

[2]. Kim YH, et al. 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Int Immunopharmacol. 2015 May;26(1):30-6.

[3]. Ahn D, et al. The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose from Curcuma longa in Caenorhabditis elegans. Biomol Ther (Seoul). 2013 Nov;21(6):442-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
1365.7±65.0 °C at 760 mmHg

[ Melting Point ]:
>250ºC dec.

[ Molecular Formula ]:
C₄₁H₃₂O₂₆

[ Molecular Weight ]:
940.677

[ Flash Point ]:
410.4±27.8 °C

[ Exact Mass ]:
940.118164

[ PSA ]:
444.18000

[ LogP ]:
8.51

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.870

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

[ Stability ]:
Hygroscopic

[ Water Solubility ]:
DMSO: ≥20mg/mL

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
2912499000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2912499000

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%