NE 100 hydrochloride

Names

[ Name ]:
NE 100 hydrochloride

[Synonym ]:
ne 100
NE-100

Biological Activity

[Description]:

NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo[1]. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death[2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53(18):PL285-90.

[2]. Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434(4):904-9.

Chemical & Physical Properties

[ Boiling Point ]:
475.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₄ClNO₂

[ Molecular Weight ]:
391.97500

[ Flash Point ]:
137.4ºC

[ Exact Mass ]:
391.22800

[ PSA ]:
21.70000

[ LogP ]:
5.78320

[ Vapour Pressure ]:
3.37E-09mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes.

Am. J. Physiol. Heart Circ. Physiol. 305(8) , H1201-12, (2013)

Although pentazocine binds to σ1-receptor (σ1R) with high affinity, the physiological relevance of its binding remains unclear. We first confirmed that σ1R stimulation with pentazocine rescues contrac...

A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells

Biochem. Biophys. Res. Commun. 434(4) , 904-9, (2013)

Highlights • NE-100 protected neuronal cells against the tunicamycin-induced cell death. • NE-100 attenuated the upregulation of CHOP induced by ER stress. • NE-100 upregulated the expressions of p50A...

Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model.

Curr. Drug Metab. 7(2) , 135-46, (2006)

The purpose of this study was to propose a new method to predict in vivo drug-drug interactions (DDIs) for a high clearance drug from in vitro data. As the high clearance drug, NE-100 (N, N-dipropyl-2...