RS 23597-190

Names

[ Name ]:
RS 23597-190

[Synonym ]:
Trequinsin hydrochloride

Biological Activity

[Description]:

RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT4 Receptor

[In Vitro]

RS 23597-190 (10 µM; 4 days) 在高葡萄糖 (30 mM)条件下显着抑制661W 细胞中超氧化物的产生[2]。

[In Vivo]

RS 23597-190 (6.0 mg/kg；静脉注射) 抑制微型猪中 5-HT 诱导的心动过速[1]. Animal Model: Bilaterally vagotomized micropig[1] Dosage: 6.0 mg/kg Administration: I.v. Result: Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min.

[References]

[1]. Eglen RM, et al. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110(1):119-26.

[2]. Du Y, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204.

Chemical & Physical Properties

[ Boiling Point ]:
486.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₄Cl₂N₂O₃

[ Molecular Weight ]:
363.27900

[ Flash Point ]:
248ºC

[ Exact Mass ]:
362.11600

[ PSA ]:
64.79000

[ LogP ]:
4.28470

[ Vapour Pressure ]:
1.29E-09mmHg at 25°C

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%