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Proadrenomedullin (1-20) (human)

Names

[ CAS No. ]:
150238-87-2

[ Name ]:
Proadrenomedullin (1-20) (human)

[Synonym ]:
Proadrenomedullin Fragment 1-20 human
1-20-Proadrenomedullin (human)
Proadrenomedullin (1-20) (human)

Biological Activity

[Description]:

Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells with an IC50 of ~350 nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a noncompetitive manner specifically at the nicotinic cholinergic receptor[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Mahata M, et al. Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension. 1998 Nov;32(5):907-16.

Chemical & Physical Properties

[ Density]:
1.47±0.1 g/cm3

[ Molecular Formula ]:
C112H178N36O27

[ Molecular Weight ]:
2460.84

[ Exact Mass ]:
2459.37000

[ PSA ]:
1075.50000

[ LogP ]:
6.08680

[ Storage condition ]:
-15°C

Related Compounds