w-Conotoxin SVIB

Names

[ CAS No. ]:
150433-82-2

[ Name ]:
w-Conotoxin SVIB

Biological Activity

[Description]:

w-Conotoxin SVIB is a peptide toxin, it can be isolated from Conus venoms. w-Conotoxin SVIB inhibits twitch response with an IC50 value of 37 nM. w-Conotoxin SVIB induces respiratory distress and it can be lethal to mice at a high concentration[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

IC50: 37 nM (twitch response at 0.1 Hz)[2]


[In Vitro]

w-Conotoxin SVIB (0.1-1000 nM; 20 min) inhibits twitch response at 0.1 Hz with an IC50 value of 37 nM[2].

[In Vivo]

w-Conotoxin SVIB (20 pmol/g; s.c. once) causes paralysis and death in fish[1]. w-Conotoxin SVIB causes mouse respiratory distress at around 70 pmol/g and it is lethal to mouse at around 300 pmol/g[1].

[References]

[1]. Ramilo CA, et al. Novel alpha- and omega-conotoxins from Conus striatus venom. Biochemistry. 1992 Oct 20;31(41):9919-26.

[2]. Hong SJ, et al. Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by omega-conotoxins GVIA, MVIIA, MVIIC and SVIB. Br J Pharmacol. 1996 Jun;118(3):797-803.

Chemical & Physical Properties

[ Molecular Formula ]:
C105H176N38O36S6

[ Storage condition ]:
−20°C

Safety Information

[ WGK Germany ]:
3

Related Compounds