Procyclidine hydrochloride

Names

[ CAS No. ]:
1508-76-5

[ Name ]:
Procyclidine hydrochloride

[Synonym ]:
Procyclidine hydrochloride
Procyclidine Hydrochloride
PROCYCLIDINE HYDROCHLORIDE

Biological Activity

[Description]:

Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

[Target]

NMDA Receptor[1]

[In Vivo]

Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1].

[Animal admin]

Rats[1] Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls.

[References]

[1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
433.5ºC at 760 mmHg

[ Melting Point ]:
85.5 to 86.5ºC

[ Molecular Formula ]:
C₁₉H₃₀ClNO

[ Molecular Weight ]:
323.90100

[ Flash Point ]:
205.7ºC

[ Exact Mass ]:
323.20200

[ PSA ]:
23.47000

[ LogP ]:
4.68030

[ Vapour Pressure ]:
2.76E-08mmHg at 25°C

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY1926000

CHEMICAL NAME :: 1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-, monohydrochloride

CAS REGISTRY NUMBER :: 1508-76-5

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H29-N-O.Cl-H

MOLECULAR WEIGHT :: 323.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,100,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5608 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UY1926000

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%