Z2CN

Names

[ CAS No. ]:
151-18-8

[ Name ]:
Z2CN

[Synonym ]:
3-Amino-1-propanethiolHCl
Propanenitrile, 3-amino-
chlorhydrate de mercapto-3 propylamine
3-amino-propionitrile
3-mercapto-1-propylamino hydrochloride
3-Aminopropionitrile
3-Mercaptopropylamine hydrochloride
EINECS 205-786-0
MFCD00014820
Z2CN
N-(2-Cyanoethyl)amine
beta-aminopropionitrile
2-Cyanoethylamine
3-cyanoethylamine
3-aminopropanonitrile
1-Propanethiol,3-aMino-,hydrochloride
3-Aminopropionitrile Fumarate
3-thiopropylamine hydrochloride
3-Aminopropanenitrile
aminopropylthiol hydrochloride
β-Aminopropionitrile
homocysteamine hydrochloride
3-aminopropanethiol hydrochloride
aminoethylcyanide

Biological Activity

[Description]:

β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

[Target]

Human Endogenous Metabolite

[In Vitro]

β-Aminopropionitrile blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibited invasion and migration capacities of cervical carcinoma cells in vitro[2].

[References]

[1]. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51.

[2]. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
186.3±13.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃H₆N₂

[ Molecular Weight ]:
70.093

[ Flash Point ]:
66.5±19.8 °C

[ Exact Mass ]:
70.053101

[ PSA ]:
49.81000

[ LogP ]:
-1.02

[ Vapour Pressure ]:
0.7±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.430

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UG0350000

CHEMICAL NAME :: Propionitrile, 3-amino-

CAS REGISTRY NUMBER :: 151-18-8

BEILSTEIN REFERENCE NO. :: 1698848

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H6-N2

MOLECULAR WEIGHT :: 70.11

WISWESSER LINE NOTATION :: Z2CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1152 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/11D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: female 14-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1250 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 1250 mg/kg

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,305,1981

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
3276

[ RTECS ]:
UG0350000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%