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Biotin-C4-amide-C5-NH2

Names

[ CAS No. ]:
151294-96-1

[ Name ]:
Biotin-C4-amide-C5-NH2

[Synonym ]:
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(4-aminobutyl)hexahydro-2-oxo-
N-(4-Aminobutyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
Biotin-C4-amide-C5-NH2

Biological Activity

[Description]:

Biotin-C4-amide-C5-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.1±0.0 g/cm3

[ Boiling Point ]:
650.1±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H26N4O2S

[ Molecular Weight ]:
314.447

[ Flash Point ]:
347.0±0.0 °C

[ Exact Mass ]:
314.177643

[ LogP ]:
0.37

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.533

Related Compounds