Zinquin

Names

[ CAS No. ]:
151606-29-0

[ Name ]:
Zinquin

[Synonym ]:
zinquin acid
Zinquin
2-methyl-8-p-toluenesulfonamido-6-quinolyloxyacetic acid
Zinquin,Free Acid

Biological Activity

[Description]:

Zinquin is a fluorescent sensor and used to observe reactive Zn2+.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[References]

[1]. Nowakowski A, et al. Sensor specific imaging of proteomic Zn2+ with zinquin and TSQ after cellular exposure to N-ethylmaleimide. Metallomics. 2012 May;4(5):448-56.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.412g/cm3

[ Boiling Point ]:
608ºC at 760 mmHg

[ Melting Point ]:
112-114ºC

[ Molecular Formula ]:
C₁₉H₁₈N₂O₅S

[ Molecular Weight ]:
386.42

[ PSA ]:
102.97000

[ LogP ]:
4.74810

[ Vapour Pressure ]:
1.23E-15mmHg at 25°C

[ Index of Refraction ]:
1.661

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Vimentin filament organization and stress sensing depend on its single cysteine residue and zinc binding.

Nat. Commun. 6 , 7287, (2015)

The vimentin filament network plays a key role in cell architecture and signalling, as well as in epithelial-mesenchymal transition. Vimentin C328 is targeted by various oxidative modifications, but i...

Sensor specific imaging of proteomic Zn2+ with zinquin and TSQ after cellular exposure to N-ethylmaleimide.

Metallomics 4(5) , 448-56, (2012)

The impact of the thiol binding reagent N-ethylmaleimide (NEM) on proteomic Zn(2+) availability was investigated in rat glioma cells. Zinquin (ZQ) or TSQ, two related fluorescent sensors, were used to...

3,3'-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblasts.

Mol. Nutr. Food. Res. 54(2) , 285-91, (2010)

3,3'-Dihydroxyisorenieratene (DHIR) is a structurally unusual carotenoid exhibiting bifunctional antioxidant properties. It is synthesized by Brevibacterium linens, used in dairy industry for the prod...