Bromo-PEG2-THP

Names

[ CAS No. ]:
152065-54-8

[ Name ]:
Bromo-PEG2-THP

[Synonym ]:
2-[2-(2-Bromoéthoxy)éthoxy]tétrahydro-2H-pyrane

Biological Activity

[Description]:

Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
314.3±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₇BrO₃

[ Molecular Weight ]:
253.13

[ Flash Point ]:
126.8±25.0 °C

[ Exact Mass ]:
252.036102

[ LogP ]:
0.95

[ Appearance of Characters ]:
Liquid

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.481

Bromo-PEG2-THP

Names

Biological Activity

Chemical & Physical Properties

Related Compounds