Veratramide

Names

[ Name ]:
Veratramide

[Synonym ]:
EINECS 216-190-5
Benzamide, 3,4-dimethoxy-
Benzamide,3,4-dimethoxy
3,4-DIMETHOXYBENZAMIDE
Veratrimidic acid
ZVR CO1 DO1
3,4-Dimethoxy-benzamide
veratroyl amine
Veratramide
3,4-dimethoxy-benzoic acid amide

Biological Activity

[Description]:

3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Feng N, et, al. Amides produced by Streptoverticillium morookaense. SAGE Journals. 2007 Jan; 2(2):151-153.

[2]. Pan Z, et, al. Preparation method of itopride hydrochloride. CN108610266A.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
278.4±25.0 °C at 760 mmHg

[ Melting Point ]:
163-164℃

[ Molecular Formula ]:
C₉H₁₁NO₃

[ Molecular Weight ]:
181.189

[ Flash Point ]:
126.1±19.5 °C

[ Exact Mass ]:
181.073898

[ PSA ]:
61.55000

[ LogP ]:
0.83

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.534

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV4367000

CHEMICAL NAME :: Benzamide, 3,4-dimethoxy-

CAS REGISTRY NUMBER :: 1521-41-1

BEILSTEIN REFERENCE NO. :: 2646714

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H11-N-O3

MOLECULAR WEIGHT :: 181.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%