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PFE-360

Names

[ CAS No. ]:
1527475-61-1

[ Name ]:
PFE-360

Biological Activity

[Description]:

PFE-360 is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].

[Related Catalog]:

Signaling Pathways >> Autophagy >> LRRK2
Research Areas >> Neurological Disease

[Target]

IC50: 2.3 nM (LRRK2 in vivo) [1][2].


[References]

[1]. Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences.

[2]. Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H16N6O

[ Molecular Weight ]:
308.34

[ Storage condition ]:
2-8°C

Related Compounds