oxypertine

Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens[1]. Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens[1].

Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain[2]. Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats[3]. Animal Model: Mice with chronic restraint stress[2] Dosage: 10, 35 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the level of homovanillic acid in three discrete regions, i.e., the cortex, striatum and mid-brain. Inhibited Apomorphine-induced stereotypy. Animal Model: Mice with stereotyped behaviour induced by amphetamine (5.0 mg/kg i.p.) and apomorphine (1.0 mg/kg, s.c.)[3] Dosage: 0.625-20 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Reduced the content of dopamine in the striatum but increased the concentrations of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC).

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C23-H29-N3-O2

MOLECULAR WEIGHT :

379.55

WISWESSER LINE NOTATION :

T56 BMJ C1 GO1 HO1 D2- AT6N DNTJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

154 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 26,186,1966