4-Boc-amino-2,2-dimethylbutyric acid

Names

[ Name ]:
4-Boc-amino-2,2-dimethylbutyric acid

[Synonym ]:
1-Boc-3-Carbamoylpiperazine

Biological Activity

[Description]:

4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.065g/cm3

[ Boiling Point ]:
369.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₂₁NO₄

[ Molecular Weight ]:
231.28900

[ Flash Point ]:
177.5ºC

[ Exact Mass ]:
231.14700

[ PSA ]:
75.63000

[ LogP ]:
2.40290

[ Vapour Pressure ]:
1.74E-06mmHg at 25°C

[ Index of Refraction ]:
1.463

4-Boc-amino-2,2-dimethylbutyric acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds