<Suppliers Price>

Gavestinel

Names

[ CAS No. ]:
153436-38-5

[ Name ]:
Gavestinel

[Synonym ]:
UNII-80W7787JVB
4,6-dichloro-3-((1E)-3-oxo-3-(phenylamino)-1-propenyl)-1H-indole-2-carboxylic acid sodium salt
Gavestinel sodium

Biological Activity

[Description]:

Gavestinel (GV 150526) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pKi of 8.5. Gavestinel can be used for the research of acute ischemic stroke[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

pKi: 8.5 (NMDA receptor)[1]


[References]

[1]. Fabio RD, et, al. Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. J Med Chem. 1997 Mar 14;40(6):841-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H11Cl2N2NaO3

[ Molecular Weight ]:
397.19

[ Exact Mass ]:
396.00400

[ PSA ]:
88.51000

[ LogP ]:
5.34680

Related Compounds