Heparastatin

Names

[ Name ]:
Heparastatin

[Synonym ]:
(3S,4S,5R,6R)-4,5-Dihydroxy-6-(2,2,2-trifluoro-acetylamino)-piperidine-3-carboxylic acid
(3S,4S,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxy-3-piperidinecarboxylic acid
(3S,4S,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxypiperidine-3-carboxylic acid

Biological Activity

[Description]:

Heparastatin is a heparanase inhibitor.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

heparanase[1].

[In Vitro]

Addition of 100 μM of Heparastatin (SF4) completely inhibits the enzyme activity of heparanase at a concentration of 0.15 μg/mL in an in vitro degradation assay. Addition of Heparastatin during the transition process does not affect the phenotypic change of TGF-β-treated cells[2].

[Cell Assay]

Influence of a heparanase inhibitor on TGF-β3-induced EMT of NMuMG cells. NMuMG cells are cultured with 1 ng/mL TGF-β3 together with 10 or 100 μM Heparastatin (SF4) for 48 h[2].

[References]

[1]. Sue M, et al. An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches. Int Immunopharmacol. 2016 Jun;35:15-21.

[2]. Yusuke Kogane, et al. Heparanase Downmodulation in the Process of Epithelial-to-Mesenchymal Transition of Mouse Mammary Epithelial Cells. Kogane et al., J Glycomics Lipidomics 2013, 3:1.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₁F₃N₂O₅

[ Molecular Weight ]:
272.17900

[ Exact Mass ]:
272.06200

[ PSA ]:
118.89000

Safety Information

[ Hazard Codes ]:
Xi