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4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid

Names

[ CAS No. ]:
1537891-69-2

[ Name ]:
4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid

[Synonym ]:
4-Methyl-4-(2-pyridinyldisulfanyl)pentanoic acid
Pentanoic acid, 4-methyl-4-(2-pyridinyldithio)-
MFCD27935396

Biological Activity

[Description]:

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
416.1±41.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H15NO2S2

[ Molecular Weight ]:
257.372

[ Flash Point ]:
205.5±27.6 °C

[ Exact Mass ]:
257.054413

[ LogP ]:
3.43

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.600


Related Compounds