Penicillin G benzathine

Names

[ Name ]:
Penicillin G benzathine

[Synonym ]:
leomypen
neolin
dibencil
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-, (2S,5R,6R)-, compd. with N,N-bis(phenylmethyl)-1,2-ethanediamine (2:1)
benzathine benzylpenicillin
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - N,N'-dibenzylethane-1,2-diamine (2:1)
benzapen
moldamin
N,N'-Dibenzylethylenedi amine bis[benzylpenicillin]
Megacillin
pendepon
DBED-penicillin
Penicillin G N,N'-dibenzylethylenediamine salt
[2S-(2a,5a,6b)]-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compd with N,N'-bis(phenylmethyl)-1,2-ethanediamine (2:1)
cillenta
N,N'-Dibenzyl-1,2-ethanediaminium bis{(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate}
penadur
Benzathine Penicillin G
bicillin
longicil

Biological Activity

[Description]:

Penicillin G benzathine (Benzathine benzylpenicillin) is an antibiotic against many bacterial infections[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Bowen AC, et al. Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. Lancet. 2014 Dec 13;384(9960):2132-40.

Chemical & Physical Properties

[ Boiling Point ]:
663.3ºCat 760 mmHg

[ Melting Point ]:
123-124ºC

[ Molecular Formula ]:
C₄₈H₅₆N₆O₈S₂

[ Molecular Weight ]:
909.124

[ Flash Point ]:
355ºC

[ Exact Mass ]:
908.360107

[ PSA ]:
248.08000

[ LogP ]:
5.72700

[ Vapour Pressure ]:
1.69E-18mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH9425000

CAS REGISTRY NUMBER :: 1538-09-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C32-H36-N4-O8-S2.C16-H20-N2

MOLECULAR WEIGHT :: 909.22

WISWESSER LINE NOTATION :: T45 ANV ESTJ CMV1R& F F GVQ & 2 &622

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,774,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,633,1954 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 22905 ug/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 82,1076,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1268 No. of Facilities: 49 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1896 (estimated) No. of Female Employees: 921 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H334

[ Precautionary Statements ]:
P261-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
XH9425000

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