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Pratosartan

Names

[ CAS No. ]:
153804-05-8

[ Name ]:
Pratosartan

[Synonym ]:
Pratosartan (JAN/INN)
UNII-66VLQ6E6DL
2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-one
KD 3-671
KT3-671
Pratosartan

Biological Activity

[Description]:

Pratosartan is a selective angiotensin II receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
Research Areas >> Cardiovascular Disease

[Target]

angiotensin II receptor[1]


[In Vitro]

Pratosartan, which is an orally active angiotensin II (AII) antagonist, exhibiting selective and potent antagonistic activity to AT1 subtype[1]. Pratosartan is a new angiotensin II type 1 receptor blocker. Pratosartan is an effective and well tolerated antihypertensive drug, and may has beneficial effect on hypertensive patients with some metabolic disorders[2].

[References]

[1]. Sonegawa M, et al. Synthesis and pharmacological activity of the metabolites of Pratosartan. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):782-7.

[2]. Ogihara T, et al. Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients. Hypertens Res. 2008 Feb;31(2):281-7.


[Related Small Molecules]

Angiotensin II acetate salt | AVE 0991 | A 779 | Tranilast | PD123319 di(trifluoroacetate) | Telmisartan | Angiotensin II Receptor Ligand | Sacubitril/valsartan (LCZ696) | EMA401 | Fimasartan | (Val5)-Angiotensin II | RE 201 | C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt

Chemical & Physical Properties

[ Density]:
1.321g/cm3

[ Boiling Point ]:
692.92ºC at 760 mmHg

[ Molecular Formula ]:
C25H26N6O

[ Molecular Weight ]:
426.51400

[ Flash Point ]:
372.864ºC

[ Exact Mass ]:
426.21700

[ PSA ]:
89.35000

[ LogP ]:
4.64010

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.701

[ Storage condition ]:
2-8℃