Plm IV inhibitor-1

Names

[ CAS No. ]:
1539276-41-9

[ Name ]:
Plm IV inhibitor-1

Biological Activity

[Description]:

Plm IV inhibitor-1 (compound 6) is a potent plasmepsin IV (Plm IV) inhibitor with IC50s of 4.1, 0.80, 0.25, 0.35 µM for Plm I, Plm II, Plm IV, Cat D, respectively[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[Target]

IC50: 4.1 µM (Plm I); 0.80 µM (Plm II); 0.25 µM (Plm IV); 0.35 µM (Cat D)[1]


[References]

[1]. Jaudzems K, et al. Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. ACS Med Chem Lett. 2014 Jan 13;5(4):373-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C37H51N5O3

[ Molecular Weight ]:
613.83

Related Compounds