HBDDE

Names

[ Name ]:
HBDDE

Biological Activity

[Description]:

HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Neurological Disease

Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKCα:43 μM (IC50)

PKCγ:50 μM (IC50)

[In Vitro]

HBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity[1]. Cell Viability Assay[1] Cell Line: Cerebellar granule cells Concentration: 50 μM Incubation Time: 5 hours Result: Reduced cell viability significantly by ~70%.

[References]

[1]. A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15.

[2]. Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200.

Chemical & Physical Properties

[ Melting Point ]:
165-168℃

[ Molecular Formula ]:
C₁₆H₁₈O₈

[ Molecular Weight ]:
338.31