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Isatidine

Names

[ CAS No. ]:
15503-86-3

[ Name ]:
Isatidine

[Synonym ]:
Retrorsine N-oxide
(3Z,5R,6S,14aR,14bR)-3-ethylidene-6-hydroxy-6-(hydroxymethyl)-5-methyl-3,4,5,6,9,11,13,14,14a,14b-decahydro[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione 12-oxide

Biological Activity

[Description]:

Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vivo]

Retrorsine N-oxide produces DNA adducts, the common biological biomarker of PA-induced liver tumor formation[1].

[References]

[1]. He X, et, al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991.

[2]. Valese AC, et, al. Quantification of pyrrolizidine alkaloids in Senecio brasiliensis, beehive pollen, and honey by LC-MS/MS. J Environ Sci Health B. 2021;56(7):685-694.

Chemical & Physical Properties

[ Melting Point ]:
138ºC (Decomp)

[ Molecular Formula ]:
C18H25NO7

[ Molecular Weight ]:
367.39400

[ Exact Mass ]:
367.16300

[ PSA ]:
122.49000

[ LogP ]:
0.13660

Safety Information

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Related Compounds