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Compound C108

Names

[ CAS No. ]:
15533-09-2

[ Name ]:
Compound C108

[Synonym ]:
2-Hydroxy-N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]benzohydrazide
Benzoic acid, 2-hydroxy-, 2-[(1E)-1-(2-hydroxyphenyl)ethylidene]hydrazide
Compound C108

Biological Activity

[Description]:

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

G3BP2[1]


[In Vitro]

Compound C108 (1 μM; 24 h) 对 BT474 细胞具有抗肿瘤活性[1]。 Compound C108 (4 μM; 24 h) 显著降低过表达 G3BP2 的 KYSE410 细胞和转染 LINC01554的 KYSE30 细胞中 G3BP2 蛋白的表达[2]。 Compound C108 (4 μM; 24 h) 减弱 KYSE410、KYSE30 和 KYSE150 细胞的 ESCC 细胞转移、迁移和侵袭[2]。 Western Blot Analysis[2] Cell Line: G3BP2-overexpressing KYSE410 cells, LINC01554-transfected KYSE30 cells Concentration: 4 μM Incubation Time: 24 h Result: Decreased the protein level of G3BP2 and HDGF.

[In Vivo]

Compound C108 (1 μM; 24 h) 靶向并减少肿瘤起始细胞 (TICs)，当把 Compound C108 处理过的 BT-474 细胞注射到雌性非肥胖糖尿病/严重联合免疫缺陷 (NOD-SCID) 小鼠的乳腺脂肪垫中，进行有限稀释异种移植试验时，Compound C108 导致肿瘤起始细胞 (TICs) 数目降低[1]。

[References]

[1]. Gupta N, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1033-1038.  

[2]. Zheng Y, et al. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript. Oncogene. 2022 Jan;41(4):515-526.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C15H14N2O3

[ Molecular Weight ]:
270.283

[ Exact Mass ]:
270.100433

[ LogP ]:
3.52

[ Index of Refraction ]:
1.607

Related Compounds