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Ibrutinib-d5

Names

[ CAS No. ]:
1553977-17-5

[ Name ]:
Ibrutinib-d5

[Synonym ]:
(R)-1-(3-(4-amino-3-(4-(perdeuterophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one

Biological Activity

[Description]:

Ibrutinib D5 (PCI-32765 D5) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[References]

[1]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H19D5N6O2

[ Molecular Weight ]:
445.52800

[ Exact Mass ]:
445.22700

[ PSA ]:
99.16000

[ LogP ]:
4.73640

Related Compounds