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Sograzepide

Names

[ CAS No. ]:
155488-25-8

[ Name ]:
Sograzepide

[Synonym ]:
UNII-HOU4I0G29C
YF-476
Sograzepide

Biological Activity

[Description]:

Sograzepide (Netazepide;YF476) is a gastrin/cholecystokinin 2 receptor (CCK2) antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor
Research Areas >> Metabolic Disease

[Target]

Gastrin/cholecystokinin 2 receptor (CCK2)[1]


[References]

[1]. Boyce M, et al. Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects. Br J Clin Pharmacol. 2015 May;79(5):744-55.


[Related Small Molecules]

Caerulein ammonium salt | Gastrin I (human) | Nastorazepide | Loxiglumide | Proglumide | Tarazepide | CCK-A receptor inhibitor 1 | CCK-B Receptor Antagonist 1 | 1H-Indole-2-carboxamide, N-[(3R)-1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk][1,4]benzodiazepin-3-yl]- | Gastrin/CCK antagonist 1 | GI 181771 | Mini Gastrin I, human | SR 146131

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
723.049ºC at 760 mmHg

[ Molecular Formula ]:
C28H30N6O3

[ Molecular Weight ]:
498.57600

[ Flash Point ]:
391.086ºC

[ Exact Mass ]:
498.23800

[ PSA ]:
119.28000

[ LogP ]:
4.04840

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds