VUF 10166

Names

[ Name ]:
VUF 10166

[Synonym ]:
Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-
Quinoxaline (2-chloro-3-(4-methyl-1-piperazinyl)
2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
VUF 10166

Biological Activity

[Description]:

VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT3A Receptor:0.04 nM (Ki)

5-HT 3 AB:22 nM (Ki)

[References]

[1]. Thompson AJ, et al. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J Pharmacol Exp Ther. 2012 May;341(2):350-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
389.6±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₅ClN₄

[ Molecular Weight ]:
262.738

[ Flash Point ]:
189.4±27.9 °C

[ Exact Mass ]:
262.098511

[ PSA ]:
32.26000

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
-20°C

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%