Safingol

Names

[ CAS No. ]:
15639-50-6

[ Name ]:
Safingol

[Synonym ]:
MFCD00792847
L-threo sphinganine,2S,3S) L-threo-2-amino-1,3-octadecanediol
L-THREO-DIHYDROSPHINGOSINE

Biological Activity

[Description]:

Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Tsukamoto S, et al. Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. Mol Cancer Ther. 2015 Oct;14(10):2303-12.

Chemical & Physical Properties

[ Density]:
0.927 g/cm3

[ Boiling Point ]:
446.2ºC at 760 mmHg

[ Melting Point ]:
106.8 - 108.7 °C

[ Molecular Formula ]:
C₁₈H₃₉NO₂

[ Molecular Weight ]:
301.50800

[ Flash Point ]:
223.7ºC

[ Exact Mass ]:
301.29800

[ PSA ]:
66.48000

[ LogP ]:
4.84850

[ Vapour Pressure ]:
7.75E-10mmHg at 25°C

[ Index of Refraction ]:
1.477

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922199090

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site.

Biochem. J. 461(2) , 213-22, (2014)

Lipid-conjugated peptides have advanced the understanding of membrane protein functions and the roles of lipids in the membrane milieu. These lipopeptides modulate various biological systems such as v...

Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.

Arch. Biochem. Biophys. 526(1) , 60-8, (2012)

The role of sphingolipids in clathrin-mediated endocytosis is only poorly understood in mammalian cells. Thus the relationship between sphingolipid de novo synthesis and clathrin-mediated endocytosis ...

Terpene alcohols inhibit de novo sphingolipid biosynthesis.

Planta Med. 78(5) , 434-9, (2012)

The terpene alcohols geranyllinalool, phytol (diterpene alcohol), and farnesol (sesquiterpene alcohol) were newly found to inhibit sphingolipid de novo biosynthesis in LLC-PK₁ cells (pig kidney epithe...