3-Pyridinecarboxylicacid, 6,6'-dithiobis-

Names

[ Name ]:
3-Pyridinecarboxylicacid, 6,6'-dithiobis-

[Synonym ]:
MFCD00006454
6,6'-Dithiobis(3-pyridinecarboxylic Acid)
EINECS 239-729-6
6,6'-Dithiodinicotinic Acid
6-[(5-carboxypyridin-2-yl)disulfanyl]pyridine-3-carboxylic acid

Biological Activity

[Description]:

6,6′-Dithiodinicotinic acid is a sulfur-containing organic compound belonging to nicotinic acid derivatives, which can be used as a specific sulfhydryl blocker[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Samir Abou-Khalil, et al. Effects of 6,6′-dithiodinicotinic acid, a thiol reagent on several mitochondrial functions: Coupling mechanism, ATPase and anion transport.Biochemical Pharmacology.Volume 24, Issue 1, 1 January 1975, Pages 49-56.

Chemical & Physical Properties

[ Density]:
1.66g/cm3

[ Boiling Point ]:
584.2ºC at 760mmHg

[ Melting Point ]:
263-265 °C(lit.)

[ Molecular Formula ]:
C₁₂H₈N₂O₄S₂

[ Molecular Weight ]:
308.33

[ Flash Point ]:
307.1ºC

[ Exact Mass ]:
307.99300

[ PSA ]:
150.98000

[ LogP ]:
2.67240

[ Vapour Pressure ]:
1.71E-14mmHg at 25°C

[ Index of Refraction ]:
1.753

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5684700

CHEMICAL NAME :: 3-Pyridinecarboxylic acid, 6,6'-dithiobis-

CAS REGISTRY NUMBER :: 15658-35-2

BEILSTEIN REFERENCE NO. :: 0426589

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H8-N2-O4-S2

MOLECULAR WEIGHT :: 308.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,559,1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
US5684700

[ HS Code ]:
2933399090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).

Chemioterapia 5(4) , 219-27, (1986)

We investigated the action of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) in vitro on murine (3T3) and baby hamster kidney (BHK) fibroblasts and an in vivo h...

Assay of biological thiols by a combination of high-performance liquid chromatography and postcolumn reaction with 6,6'-dithiodinicotinic acid.

Anal. Biochem. 138(1) , 95-8, (1984)

A simple and rapid method for the determination of nanomole levels of biological thiols is described. The analysis is based on the combination of reverse-phase high-performance liquid chromatography w...

Role of membrane-associated thiol groups in the functional regulation of gastric microsomal (H+ + K+)-transporting ATPase system.

Biochem. J. 213(3) , 587-94, (1983)

The distribution of free thiol groups associated with the membrane proteins of the purified pig gastric microsomal vesicles was quantified, and the relation of thiol groups to the function of the gast...