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Org 20599

Names

[ CAS No. ]:
156685-94-8

[ Name ]:
Org 20599

[Synonym ]:
YS-035 hydrochloride

Biological Activity

[Description]:

Org20599 is a positive allosteric modulator and at higher concentrations direct agonist of GABAA receptor with an EC50 of 1.1 μM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Visser SA, et al. Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo. J Pharmacol Exp Ther. 2002 Nov;303(2):616-26.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₄₀ClNO₃

[ Molecular Weight ]:
438.04300

[ Exact Mass ]:
437.27000

[ PSA ]:
49.77000

[ LogP ]:
4.06270

Related Compounds