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(R)-SCH 42495

Names

[ CAS No. ]:
156792-25-5

[ Name ]:
(R)-SCH 42495

Biological Activity

[Description]:

(R)-SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354[2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

NEP acts as a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro[1].

[In Vivo]

Inhibition of NEP in vivo has been shown to produce beneficial vasodilatory and natriuretic responses[1].

[References]

[1]. Neustadt BR, et al. Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem. 1994 Jul 22;37(15):2461-76.

[2]. Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H29NO4S2

[ Molecular Weight ]:
411.58

Related Compounds