Dimethyl-bisphenol A

Names

[ Name ]:
Dimethyl-bisphenol A

[Synonym ]:
2,2-Bis-(4-methoxy-phenyl)-propan
2,2-bis(4-methoxyphenyl)propane
BISPHENOL A DIMETHYL ETHER
methoxybisphenol A
Dimethyl-Bisphenol A

Biological Activity

[Description]:

Dimethyl-bisphenol A (DMBPA) is a potent HIF-1α inhibitor. Dimethyl-bisphenol A can decrease Vegfa mRNA expression[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[In Vitro]

Dimethyl-bisphenol A (DMBPA; 50 μM; 30 min) significantly inhibits Vegfa120 and Vegfa164 expression in large osteoclasts (OCs)[1].

[References]

[1]. Diana P Trebec-Reynolds, et al. VEGF-A expression in osteoclasts is regulated by NF-kappaB induction of HIF-1alpha. J Cell Biochem. 2010 May 15;110(2):343-51.

Chemical & Physical Properties

[ Density]:
1.022g/cm3

[ Boiling Point ]:
364.8ºC at 760 mmHg

[ Melting Point ]:
54-59ºC

[ Molecular Formula ]:
C₁₇H₂₀O₂

[ Molecular Weight ]:
256.34

[ Flash Point ]:
136.3ºC

[ Exact Mass ]:
256.14600

[ PSA ]:
18.46000

[ LogP ]:
4.02970

[ Vapour Pressure ]:
3.45E-05mmHg at 25°C

[ Index of Refraction ]:
1.532

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39

[ HS Code ]:
2909309090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%