naftazone

Names

[ Name ]:
naftazone

[Synonym ]:
Mediaven
Naftazone (INN)
Naftazona
Naftazonum
Naftazone
1,2-Naphthochinon-2-semicarbazon
[1,2]naphthoquinone-2-semicarbazone
Mediavene
1,2-naphthoquinone semicarbazone
Karbinone
Mediaven (TN)

Biological Activity

[Description]:

Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vitro]

Naftazone (0.5-50 μM; 1 h) reduces glutamate release from mouse cerebellum synaptosomes[1].

[In Vivo]

Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid[1]. Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats[2]. Animal Model: Male rats[1] Dosage: 10 and 100 mg/kg Administration: Oral gavage; 10 and 100 mg/kg once per day; for 15 days Result: Significantly reduced glutamate content in cerebro spinal fluid of rats. Animal Model: Wistar rats[2] Dosage: 50 mg/kg Administration: Intraperitoneal injection ; 50 mg/kg once daily for 5 days Result: Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet.

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Molecular Formula ]:
C₁₁H₉N₃O₂

[ Molecular Weight ]:
215.20800

[ Exact Mass ]:
215.06900

[ PSA ]:
84.55000

[ LogP ]:
2.01160

[ Index of Refraction ]:
1.678

Safety Information

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%