OSU 6162 hydrochloride

Names

[ Name ]:
OSU 6162 hydrochloride

[Synonym ]:
OSU-6162
(S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride
OSU6162 hydrochloride
(S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
OSU 6162 HYDROCHLORIDE
PNU-0096391
OSU-6162 hydrochloride

Biological Activity

[Description]:

(-)-OSU6162 (PNU96391) hydrochloride is a dopamine stabilizer. (-)-OSU6162 hydrochloride acts as partial agonist at 5-HT2A and is a dopamine D2 antagonist. (-)-OSU6162 hydrochloride can be used for the research of aggression and irritability[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Carlsson ML, et al. I. In vivo evidence for partial agonist effects of (-)-OSU6162 and (+)-OSU6162 on 5-HT2A serotonin receptors. J Neural Transm (Vienna). 2011 Nov;118(11):1511-22.

[2]. Studer E, et al. The effects of the dopamine stabilizer (-)-OSU6162 on aggressive and sexual behavior in rodents. Transl Psychiatry. 2016 Mar 22;6(3):e762.

Chemical & Physical Properties

[ Boiling Point ]:
436.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₄ClNO₂S

[ Molecular Weight ]:
317.87

[ Flash Point ]:
217.8ºC

[ Exact Mass ]:
317.12200

[ PSA ]:
45.76000

[ LogP ]:
4.50020

[ Vapour Pressure ]:
8.04E-08mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Articles

The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects.

Neuropsychopharmacology 40(2) , 472-9, (2015)

(-)-OSU6162 is a dopamine stabilizer that can counteract both hyperdopaminergic and hypodopaminergic states. In this study, D2/D3 receptor occupancy of (-)-OSU6162 in the human brain was investigated ...