N-((9H-fluoren-9-ylmethoxy)carbonyl)-N,O-dimethyl-L-Serine

Names

[ Name ]:
N-((9H-fluoren-9-ylmethoxy)carbonyl)-N,O-dimethyl-L-Serine

Biological Activity

[Description]:

N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Yao G, et al. Efficient Synthesis and Stereochemical Revision of Coibamide A. J Am Chem Soc. 2015 Oct 28;137(42):13488-91.

[2]. Tranter D, et al. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins. ACS Chem Biol. 2020 Aug 21;15(8):2125-2136.

Chemical & Physical Properties

[ Density]:
1.266±0.06 g/cm3(Predicted)

[ Boiling Point ]:
540.6±50.0 °C(Predicted)

[ Molecular Formula ]:
C₂₀H₂₁NO₅

[ Molecular Weight ]:
355.38444

[ Storage condition ]:
2-8°C