Chrysotoxine

Names

[ Name ]:
Chrysotoxine

[Synonym ]:
Phenol,4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy

Biological Activity

[Description]:

Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364(2):332-346.

[2]. Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₂O₅

[ Molecular Weight ]:
318.36

[ Exact Mass ]:
318.14700

[ PSA ]:
57.15000

[ LogP ]:
3.21180

[ Storage condition ]:
-20°C