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OS-3-106

Names

[ CAS No. ]:
1580000-17-4

[ Name ]:
OS-3-106

[Synonym ]:
MFCD28118985
N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-4-(1,3-thiazol-4-yl)benzamide
Benzamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-4-(4-thiazolyl)-

Biological Activity

[Description]:

OS-3-106 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (Ki = 0.2 nM) at the D3R. OS-3-106 reduces cocaine self-administration and sucrose reinforcement rates. OS-3-106 can be used for psychostimulant addiction research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

D3 Receptor:0.2 nM (Ki)

D2 Receptor


[In Vitro]

OS-3-106 exhibits 115-fold binding selectivity for the D3R compared with the D2R[1].

[References]

[1]. Cheung TH, et al. Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55. J Pharmacol Exp Ther. 2013 Nov;347(2):410-23.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
671.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H30N4O2S

[ Molecular Weight ]:
450.60

[ Flash Point ]:
359.8±31.5 °C

[ Exact Mass ]:
450.208954

[ LogP ]:
4.10

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.597

Related Compounds