MSN-125

Names

[ Name ]:
MSN-125

Biological Activity

[Description]:

MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM; potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Bax

Bak

[In Vitro]

MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].

[References]

[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₃₈BrN₃O₆

[ Molecular Weight ]:
688.619

Safety Information

[ Hazard Codes ]:
Xi

MSN-125

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds