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Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

Names

[ CAS No. ]:
159439-02-8

[ Name ]:
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

[Synonym ]:
N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid
N-ACETYL-O-PHOSPHONO-TYR-GLU-GLU-ILE-GLU
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Glu-Ile-Glu
AC-YEEIE
AC-PYEEIE TRIFLUOROACETATE SALT
N-ACETYL-O-PHOSPHONE-TYR-GLU*DIPENTYLAMI
M.W. 803.71 C32H46N5O17P
L-Glutamic acid, N-acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-

Biological Activity

[Description]:

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

[References]

[1]. G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C32H46N5O17P

[ Molecular Weight ]:
803.705

[ Exact Mass ]:
803.262634

[ PSA ]:
371.27000

[ LogP ]:
-2.73

[ Index of Refraction ]:
1.573

Related Compounds